What is hypoxia?
Hypoxia is a condition that results from not enough oxygen supply to tissues in the body. This can be caused by inadequate delivery or the tissues using more oxygen. 1
The air we breathe contains 21 percent oxygen. The level of oxygen in our body is a measure of oxygen the red blood cells are carrying. In adequate oxygenation, the blood contains normal concentrations of haemoglobin. 2
Oxygenation can be measured with:
Oxygen saturation (SaO2) – using a pulse oximeter to measure haemoglobin bound to oxygen compared to haemoglobin not bound to oxygen. 3 4
Partial pressure of oxygen (PO2) – arterial blood gas analysis to determine the amount of oxygen gas dissolved in the blood. 1
In most people the percentage of oxygen in the blood is above the SpO2 level of 92 per cent and the PO2 is 75 to 100 mmHg. 3
Hypoxia can result from hypoxaemia (low oxygen levels in the blood), anaemia, and/or inadequate oxygen delivery. If the body compensates with an increase in haemoglobin and cardiac output, hypoxaemia can occur without hypoxia. 1
Sometimes medical conditions affect the body’s ability to compensate for this short fall. In these cases home oxygen therapy is prescribed home oxygen therapy can ensure enough oxygen gets to the vital organs.
The aim is to achieve normal oxygen levels in the blood. Depending on the medical condition, home oxygen therapy can improve quality of life. 5
What are the symptoms indicating the need for home oxygen therapy?
Symptoms most common with hypoxia are shortness of breath with hypoxaemia. Others symptoms include coughing, wheezing and changes in skin colour. More dangerous symptoms are drowsiness, loss of memory, tachycardia (fast heart rate); and bradycardia (slow heart rate). 6 7
What conditions with hypoxia need oxygen home therapy?
The indications for home oxygen therapy are based on the medical condition and tests to determine oxygen measurements in the blood. These can be due to the presence of arterial blood gases (at rest/night/exertion) with room air, cardiac disease or because the patient is in palliative care. 2 8
Symptoms of hypoxia can be caused by respiratory medical conditions such as asthma, sleep-related breathing disorders having pulmonary hypertension or interstitial pulmonary fibrosis or malignancy.
It can also be caused by cardiac conditions such as chronic obstructive pulmonary disease; ischaemic heart disease, cardiac failure or other conditions (terminal illness and cluster headache). 2 4 6 8
What are the complications of hypoxia?
The three main complications associated with hypoxia are difficulty converting energy without (anaerobic metabolism), cellular acidosis or cell death and the main one, organ failure1 .
Continued hypoxia leads to anaerobic metabolism, cell damage and lactic acid release. The lactic acid can injure tissues in the lungs, liver, kidneys, heart and brain. 1
What are the tests for home oxygen therapy?
TEST | DESCRIPTION |
Chronic hypoxia PO2 pH PCO2 | Partial pressure of oxygenAmount of oxygen dissolved in arterial blood. Potential of hydrogenMeasure of hydrogen ions determining acidity and alkalinity in arterial blood. Partial pressure of carbon dioxideMeasure of carbon dioxide dissolved in arterial blood. |
Nocturnal or exertional hypoxia Oxygen saturation | Per cent fraction of oxygen-saturated haemoglobinMeasure of haemoglobin bound to oxygen compared to haemoglobin not bound to oxygen. |
If the criteria is met for home oxygen therapy the prescription will include rate of flow of oxygen, duration for use, oxygen supply equipment; and respiratory home therapy appliances.
The prescription for the type of oxygen therapy tank depends on a person’s mobility, strength, breathing preference (nose or mouth) and the oxygen flow required. 7
Compressed oxygen gas cylinder (OGC) for stationary use only – contains a purity level of oxygen (no less than 99.5 per cent). The gas from the cylinder can be used for a ‘home-fill’ of a smaller portable cylinder. They vary in different sizes.
Home oxygen concentrator (HOC) – draws in room air (21 percent oxygen and 79 percent nitrogen) and processes it to 90 – 95 percent oxygen. The two types of oxygen concentrators are stationary and portable. They need a power source or battery. 2
Oxygen therapy machines
Raising the head of the bed can improve oxygenation, reduce acid reflux, lower pressures in the brain and prevent obstructive sleep apnoea. 9 10
Deep breathing techniques increase oxygen saturations and lung capacity.
What type of health professional can prescribe home oxygen therapy?
In Australia a registered nurse, a physiotherapist or a general practitioner the following health professionals can prescribe/order homemedical oxygen therapy, along with a local medical officer, respiratory physician an Oncologist and a Cardiologist 11
Oxygen safety precautions
Support for oxygen therapy at home
Community Health Centre
References
Home-care guidelines for adult patients with mild COVID-19
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